Table 5.
Association of intensive BP target on cognitive impairment in baseline model, and with adjustment for baseline eGFR or postrandomization eGFR declines
eGFR, ml/min per 1.73 m2 | HR (95% CI) for Intensive versus Standard | ||
---|---|---|---|
Probable Dementia | MCI | Probable Dementia or MCI | |
Original | 0.83 (0.67 to 1.04) | 0.81 (0.69 to 0.94) | 0.85 (0.74 to 0.97) |
Baseline eGFR <60 model | 0.82 (0.66 to 1.03) | 0.80 (0.69 to 0.94) | 0.84 (0.74 to 0.96) |
Decline in eGFR ≥30% model | 0.85 (0.69 to 1.06) | 0.84 (0.72 to 0.99) | 0.88 (0.77 to 1.01) |
Incident eGFR <60 model | 0.84 (0.63 to 1.12) | 0.73 (0.60 to 0.89) | 0.80 (0.67 to 0.94) |