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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: J Cell Physiol. 2018 Feb 28;233(8):5503–5512. doi: 10.1002/jcp.26418

FIGURE 3.

FIGURE 3

Caveolin (CAV)-1 protein expression downregulation in lung and skin wounds of BLM-treated mice was prevented by systemic ASC treatment. Western blots were performed on skin wound (a) and lung (b) tissue from aged C57BL/6 mice treated with saline, BLM, and BLM + ASC to measure protein expression of CAV-1. BLM resulted in downregulation of CAV-1 expression compared to saline-treated controls in both skin wound and lungs. ASC treatment resulted in a prevention of this BLM-induced CAV-1 downregulation. Inset shows a representative Western blot of three mice per treatment group. Full-length blots are presented in Supplementary Figure S1. Data are graphed as mean ± standard error of the mean (n = 6/group). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001