TABLE 1.
Expression of markers of fibrosis and inflammation in mice with bleomycin-induced lung injury and delayed wound healing
Group (n = 6/group) | αvintegrin mRNA/18S | TNF-α mRNA/18S |
---|---|---|
Skin wound | ||
Saline | 0.0806 ± 0.0193 | 1.641 ± 0.3802 |
Bleomycin only | 0.4322 ± 0.1215* | 32.71 ± 13.38* |
Bleomycin + ASCs | 0.0526 ± 0.0140**** | 1.352 ± 0.2375*** |
Lung | ||
Saline | 0.5343 ± 0.1569 | 8.714 ± 1.786 |
Bleomycin only | 1.484 ± 0.2556** | 15.22 ± 2.168* |
Bleomycin + ASCs | 0.4048 ± 0.2964*** | 5.701 ± 2.649*** |
ASCs, adipose-derived mesenchymal stem cells.
p < 0.05 versus saline;
p < 0.01 versus saline;
p < 0.05 versus BLM only;
p < 0.01 versus BLM only.