Table 2.
Results of 31P-MT-MRS Measurements in the Human Frontal Lobe of Schizophrenia and Healthy Controls
| Schizophrenia (N=26) |
Healthy
control (N=26) |
Statistics (p value) |
||
|---|---|---|---|---|
| Magnetization ratio | PCr/β-ATP | 1.35±0.24 | 1.36±0.17 | 0.705 |
| Pi/β-ATP | 0.44±0.09 | 0.42±0.07 | 0.473 | |
| PDE/β-ATP | 0.91±0.19 | 1.05±0.19 | 0.015 | |
| PME/β-ATP | 1.05±0.14 | 1.09±0.16 | 0.544 | |
| pH | 7.00±0.02 | 7.03±0.01 | 0.0072 | |
| 1M*/M0 of PCr | 0.50±0.12 | 0.43±0.07 | 0.013 | |
| Rate constant kf (−1s) of CK | 0.21±0.07 | 0.27±0.06 | 0.003 | |
| T1(s) of PCr | 5.21±1.24 | 5.03±1.09 | 0.67 | |
| Chemical exchange flux of CK (μmol/g/min) | 49.93±21.95 | 61.43±16.08 | 0.032 | |
| [Mg2+] (mmol/L) | 0.149±0.026 | 0.145±0.027 | 0.590 | |
1.
Magnetization ratios between steady-state saturation (M*, 12.28s saturation time) and control (M0), unsaturated.
2.
Including adjustment for BMI