FIGURE 6.

Viral control in CD8 T-cell deficient and B cell deficient mice when challenged i.c. with YF-17D virus during the effector and memory phase. WT C57BL/6, MHC class I CD8 T-cell deficient (K^b/D^b) and B cell deficient (μMT) mice were vaccinated with 1 × 10⁵ pfu YF-17D s.c. and 1 week or 8 weeks later, these mice along with naive control mice, were challenged with 1 × 10⁴ pfu YF-17D i.c. Health status was monitored daily and on day 7 post i.c. challenge, brains were removed and viral titers were measured by an immune focus assay. The detection limit for virus in brain was 200 pfu/g organ and is displayed as a stippled line. The results represent the group medians and each dot represents one animal, *p < 0.05.