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. 2020 Aug 18;11:969. doi: 10.3389/fgene.2020.00969

FIGURE 2.

FIGURE 2

Models of GroEL (light brown) and hHsp60 (blue) wild type monomers superimposed and location of some of the amino acids found mutated in hHsp60 (light blue spheres), and their corresponding amino acids in GroEL (brown spheres). For both molecules, the nucleotide is colored in red. Models were built using SWISS-MODEL and visualized with PyMOL. (A) GroEL leucine 31 and hHsp60 methionine 55; (B) GroEL arginine 197 and hHsp60 arginine 221; (C) GroEL tyrosine 199 and hHsp60 tyrosine 223; (D) GroEL alanine 241 and hHsp60 asparagine 265; (E) GroEL valine 263 and hHsp60 valine 287; (F) GroEL glutamic acid 304 and hHsp60 glutamic acid 328; (G) GroEL asparagine 479 and hHsp60 aspartic acid 504; (H) GroEL alanine 480 and hHsp60 alanine 505; (I) GroEL alanine 581 and hHsp60 methionine 506; (J) GroEL aspartic acid 5 and hHsp60 aspartic acid 29; (K) GroEL valine 74 and hHsp60 valine 98; (L) GroEL glutamine 436 and hHsp60 glutamine 461 (the molecules were rotated 200 degrees around the y-axis compared to the other figures).