Table 2.
The basic characteristics of the long pentraxins.
| Characteristics | NPTX1 | NPTX2 | NPTXR | PTX3 | PTX4 |
|---|---|---|---|---|---|
| Genomic location | 17q25.3 | 7q22.1 | 22q13.1 | 3q25.32 | 16p13.3 |
| Sequence features | 150 bp of 5' UTR, 1.3 kb coding sequence, 3.6 kb 3' UTR | 1.3 kb coding sequence, 1.2 kb 3'-UTR | 5.5 kb in length, 3.9 kb of 3' UTR, 1.5 kb open reading frame | 68 bp of 5' UTR, 650 bp of 3' UTR, | – |
| Domain structures | Pentraxin-related, Pentraxin_CS, ConA-like_dom_sf | Pentraxin-related, Pentraxin_CS,ConA-like_dom_sf | Pentraxin-related, ConA-like_dom_sf, N-terminal transmembrane domain | Pentraxin-related, Pentraxin_CS, ConA-like_dom_sf | Pentraxin-related, Pentraxin_CS,ConA-like_dom_sf |
| Top tissue expression | Brain | Brain, liver, testis, skeletal muscle, heart, pancreas | Brain | Monocytes, macrophage, fibroblasts, epithelial cells | Thymus, spleen, small intestine, liver |
| Signaling pathway | HIF-1 signaling pathway (65), IRS-1/PI3K/Akt signaling pathway (66), JNK and GSK3 signaling pathways (67), Rb/E2F pathway (68), Nodal and BMP signaling pathway (69) | Wnt/β-catenin signaling pathway (70), p53/PTEN/Akt/NF-κB signaling pathway (71) | – | Akt/NF-kB signaling pathway (9), JNK signaling pathway (72), IL-6/Stat3 signaling pathway (73), PI3K signaling pathway (74) | – |
NPTX1, neuronal pentraxin 1; NPTX2, neuronal pentraxin 2; NPTXR, neuronal pentraxin receptor; PTX3, pentraxin 3; PTX4, pentraxin 4; UTR, un-translated region; Domain structure were obtained from the Genecard database.