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Diagram illustrating the binding of VP16 to gH and binding to the envelope through VP22. When the nucleocapsid is transported to the vesicle derived from the Golgi membrane, VP16 on the capsid cannot only directly bind to some glycoproteins on the envelope but also combine with the envelope through some tegument proteins to promote the secondary envelope of the nucleocapsid (Diefenbach, 2015; Owen et al., 2015).
