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. 2020 Aug 18;14:848. doi: 10.3389/fnins.2020.00848

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Copyright © 2020 Wang, Ru, Zhang, Chen, Lin, Lin, Wen, Huang, Ni, Zhuge and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exosome treatment reduced brain damage and promoted functional recovery after stroke. (A) Neurological recovery was evaluated by the modified neurological severity score (mNSS) at 1, 7, 14, 21, and 28 days post-permanent distal middle cerebral artery occlusion (pMCAO, n = 12). (B,C) Representative images of 2,3,5-triphenyltetrazolium chloride (TTC) staining in five sequential brain slices from the various groups of rats (n = 3). (D) Brain water content was evaluated at 72 h post-injury (n = 4). Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the pMCAO group. ^##P < 0.01, ^###P < 0.001 vs. the EXO1 (basic plasma exosomes) group.