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. 2020 Aug 18;11:1787. doi: 10.3389/fimmu.2020.01787

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Copyright © 2020 You, Han, Zhu, Zhu, Bao, Yang, Lei and Qian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human anti-CD123 specific T cells are generated by transducing chimeric CD123-CAR lentivirus. (A) Schematic representation of CD123-CAR structure. The CD123-CAR expression cassette is under the regulation of EF1α promoter, and mainly composed of an extracellular CD123-binding scFv, a 4-1BB costimulatory domain, and CD3ζ endodomains. (B,C) The transduction efficiency of T cells from patients (n = 2) and healthy donors (n = 3) was confirmed by fluorescence-activated cell sorting (FACS) analysis as described in Materials and Methods. Representative data of one healthy donor was presented (B). The average expression (Mean ± SD) of CD123-CAR in transduced T cells from patients and healthy donors was shown respectively (C).