Table 3.
IVIM-DWI and pathological parameters in different time points from Group C.
| Group C | Base | Day 3 | Day 6 | Day 9 | Day 12 | Day 15 | F | P |
|---|---|---|---|---|---|---|---|---|
| D (10−3 mm2/s) | 0.566 ± 0.029 | 0.582 ± 0.023 | 0.620 ± 0.022 | 0.650 ± 0.024 | 0.664 ± 0.041 | 0.665 ± 0.032 | 17.116 | 0.001 |
| D* (10−3 mm2/s) | 7.17 ± 0.38 | 7.89 ± 0.52 | 7.94 ± 0.63 | 7.64 ± 0.48 | 7.79 ± 0.59 | 8.17 ± 0.37 | 3.665 | 0.008 |
| f (%) | 16.9 ± 0.9 | 17.5 ± 1.0 | 18.0 ± 0.7 | 16.9 ± 0.9 | 16.4 ± 0.7 | 16.6 ± 0.8 | 4.181 | 0.004 |
| VMI (%) | 54.9 ± 3.4 | 53.0 ± 3.6 | 52.7 ± 3.7 | 50.5 ± 3.2 | 49.2 ± 3.2 | 50.9 ± 3.0 | 2.963 | 0.022 |
| MVD | 15.0 ± 1.0 | 17.3 ± 0.6 | 18.0 ± 1.0 | 15.3 ± 0.6 | 14.7 ± 0.6 | 14.5 ± 1.8 | 4.825 | 0.006 |
| VM | 4.3 ± 1.2 | 4.3 ± 1.5 | 4.3 ± 1.5 | 3.7 ± 0.6 | 3.7 ± 0.6 | 2.8 ± 0.7 | 2.762 | 0.045 |
| Ki-67 (%) | 38.4 ± 1.0 | 39.8 ± 1.8 | 36.9 ± 1.8 | 35.5 ± 1.1 | 35.6 ± 2.7 | 34.2 ± 1.7 | 5.634 | 0.003 |
| E-cadherin (%) | 23.7 ± 1.2 | 23.4 ± 1.9 | 24.4 ± 0.8 | 23.7 ± 1.1 | 24.1 ± 1.6 | 28.0 ± 1.1 | 11.67 | 0.001 |
| Tumor volume (mm3) | 218.5 ± 29.6 | 303.4 ± 30.1 | 360.5 ± 16.9 | 425.9 ± 35.8 | 465.9 ± 32.1 | 561.1 ± 36.1 | 125.249 | 0.001 |
Repeated measures analysis of variance was used to generate the P-value. IVIM-DWI, intravoxel incoherent motion diffusion-weighted imaging; VMI, vascular maturity index; MVD, microvessel density; VM, vasculogenic mimicry.