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. 2020 Aug 18;11:2040. doi: 10.3389/fimmu.2020.02040

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Copyright © 2020 Zhang, Wang, Jiang, Lin, Luo, Zhao, Tan and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AdipoR1 knockout in T cells ameliorates antigen-induced arthritis (AIA) disease. (A) Timeline of AIA induction. (B) Weights were recorded daily after the 3rd immunization (n = 5). (C) Mean diameters of knee joints were recorded daily after the 3rd immunization (n = 5). (D) Photomicrographs for knee joint sections stained with H&E on day 25 (original magnification 100×) (n = 3–5). Photomicrographs of immunohistochemical staining of IL-6, TNFα and IL-1β in knee joint tissues on day 25, positive cells were stained with intense brown color (original magnification 400×) (n = 3). Knee joints were stained for TRAP positivity (left) on day 25 post AIA (original magnification 400×) and quantified by computer analysis (n = 3). Proteoglycan staining was demonstrated by safranin O-fast green immunostaining (original magnification 200×) (n = 3) (*p < 0.05, **p < 0.01, and ***p < 0.001).