Figure 7.

Correlations between antibody titer, subclass, and psoriasis severity. Increased IgG1 correlates with improved psoriasis (decreased epidermal thickness) (A), while increased IgG2b correlates with exacerbated psoriasis (increased epidermal thickness) (B). A heatmap of epidermal thickness illustrates a target region (green) for reduced epidermal thickening (C). Analysis was carried out by simple linear regression. Data shown represent a combination of two separately conducted experiments: Experiment 1: CpG n = 5 and unadjuvanted n = 5; Experiment 2: alum n = 5 and unadjuvanted n = 5.