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. 2020 Aug 18;11:2063. doi: 10.3389/fimmu.2020.02063

Figure 2.

Figure 2

Principal component analysis of laboratory parameters and dynamic monitoring of blood cells in the peripheral blood of COVID-19 patients. (A) Principal component analysis to identify variables for distinguishing the disease severity of COVID-19 patients. The nine variables that contributed mostly to distinguishing the disease severity were white blood cell counts (WBC), neutrophil counts, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), FIB, ALT, Total Bilirubin (TB), Direct Bilirubin (DB), and lymphocyte counts. (B) CRP levels and lymphocyte counts in 55 cases with the cut-off values CRP = 26.1 and lymphocyte = 1.0 for eight severe cases (brown) and the cut-off values CRP = 4.3 and lymphocyte = 1.4 for 22 mild cases (green). (C) The dynamic change of neutrophil, lymphocyte and monocyte counts over time in COVID-19 patients in mild (cyan), moderate (blue), and severe (red) groups, circled dots: mean value; colored background area: IQR (interval quartile range). The (D) Time points of maximum neutrophil, minimum lymphocyte, and minimum monocyte counts, and the corresponding counts in mild (cyan), moderate (blue), and severe (red) COVID-19 patients during hospitalization.