Skip to main content
. 2020 Aug 18;11:871. doi: 10.3389/fgene.2020.00871

Figure 3.

Figure 3

LincRNA-p21 is required for the adaptive dynamics of HIF-1α. (A) Comparison of [lincRNA-p21] at 24 h for different O2 levels between simulation (circle) and experiment (black square). The experimental data are retrieved from Yang et al. (2014). (B,C) Time courses of [HIF-1αtot] (B) and [lincRNA-p21] (C) with normal lincRNA-p21 expression (solid, ksLAp21 = 0.08 and ksLAp21a = 0.05) and knockout (dashed, ksLAp21 = 0 and ksLAp21a = 0) at 1% O2. Black squares denote the experimental data for [HIF-1αtot] and [lincRNA-p21] with normal lincRNA-p21 expression, retrieved from Yang et al. (2014). (D) With inhibited protein synthesis (kthif = 0), time courses of [HIF-1αtot] with normal lincRNA-p21 expression (solid, ksLAp21 = 0.08 and ksLAp21a = 0.05) and knockout (dashed, ksLAp21 = 0 and ksLAp21a = 0) under 1% O2. Of note, the initial state refers to the transient state at 24 h under 1% O2 in the standard parameter setting.