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. 2020 Aug 18;10:1507. doi: 10.3389/fonc.2020.01507

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Copyright © 2020 Liu, Zhang, Liu, Sun, Guo, Tang, Wang, Li, He, Zhang, Wang, Li, Fan, Tsang, Zhang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-dependent metabolomics/lipidomics characteristics. (A) Score plot of PLS-DA model for three age groups based on plasma metabolomics in females and males. Metabolic profiling varied with age in both males and females. Differential metabolites and pathways with respect to aging in male (B) and female (C). Heat maps showing the relative abundance of age-dependent metabolites/lipids in male (D) and female (E) these performing important biological functions. (F) Highlighted pathways contain specific metabolites showing differences with age in male and female. (A) Was created using simca 14.0; (B,C) Were created using MetaboAnalyst 3.0; (D,E) Were created using R package; (F) Was created using Microsoft office PPT 2007.