TABLE 1.

Summary of neovessel invasion findings.

Experimental condition	Key observations	Conclusion/Implication
Neovessels alone	Neovessels do not cross interface
Neovessels + SVF in core	Neovessels cross interface	Stromal cells promote neovessel invasion
Neovessels + SVF in field	Neovessels cross interface
SVF in collagen gels	Express VEGF-A	VEGF-A presence is necessary but not sufficient for SVF-enabled neovessel invasion
Neovessels + SVF + anti-VEGF	Neovessels do not cross interface
Neovessels + recombinant VEGF	Neovessels do not cross interface
SHG of fibril architecture	Fibrils at interface are dense	Deflection of neovessels at the interface is due to collagen fibril density at the interface.
Simulation: increased interface density	Neovessels do not cross interface
Simulation: fibril alignment at interface	Neovessels cross interface without high initial density