Table 1.
Principal characteristics of the CADASIL patients in this study.
| Characteristics | Total CADASIL (n = 37) |
|---|---|
| Risk factors | |
| Age at time of study entry, y, (mean ±SE) | 47.5 ± 9.7 |
| Male, n (%) | 17 (45.9) |
| Hypertension, n (%) | 10 (27.0) |
| Smoking, n (%) | 10 (27.0) |
| Hypercholesterolemia, n (%) | 15 (40.5) |
| Diabetes, n (%) | 2 (5.4) |
| Clinical and genetic characteristics | |
| Disease duration, year, (median, range) | 6.5 ± 5.5 |
| Ischemic stroke, n (%) | 26 (70.3) |
| Hemorrhagic stroke, n (%) | 5 (13.5) |
| Cognitive impairment, n (%) | 30 (81.1) |
| Large arteries neuroimaging characteristics | |
| Artery stenosis, n (%) | 8 (21.6) |
| Tortuosity, n (%) | 13 (35.1) |
| Prolongation, n (%) | 1 (2.7) |
| BSA fenestration | 4 (10.8) |
| VA hypoplasia or agenesis | 14 (37.8) |
| FPCA and ACA share common trunk | 5 (13.5) |
| Small vessels neuroimaging characteristics | |
| Fazekas score (IQR) | 3 (2–3) |
| Presence of lacuna, n (%) | 24 (64.9) |
| Presence of CMB, n (%) | 19 (51.4) |
| Presence of EPVS, n (%) | 31 (83.8) |
ACA, anterior cerebral artery; BSA, basilar artery; CADASIL, cerebral autosomal dominant with subcortical infarcts and leukoencephalopathy; CMB, cerebral microbleeds; EPVS, enlarged perivascular spaces; FPCA, fetal posterior cerebral artery; IQR, interquartile range; SE, standard error; SVD, small vessel disease; VA, vertebral artery.