Table 2.
Comparison of demographic and neuroimaging characteristics between CADASIL and leukoaraiosis without genetic SVD.
| Characteristics | CADASIL (n = 37) | Control (n = 38) | P-value |
|---|---|---|---|
| Risk factors | |||
| Age at time of study entry, y, (mean ±SE) | 47.5 ± 9.7 | 51.3 ± 7.7 | 0.066 |
| Male, n (%) | 17 (45.9) | 20 (52.6) | 0.647 |
| Hypertension, n (%) | 10 (27.0) | 31 (81.6) | 0.000 |
| Smoking, n (%) | 10 (27.0) | 21 (55.3) | 0.019 |
| Hyperlipidemia, n (%) | 15 (40.5) | 12 (31.6) | 0.476 |
| Diabetes, n (%) | 2 (5.4) | 8 (21.1) | 0.086 |
| Large vessels neuroimaging characteristics | |||
| Artery stenosis, n (%) | 8 (21.6) | 4 (10.5) | 0.222 |
| Tortuosity, n (%) | 13 (35.1) | 8 (21.1) | 0.206 |
| Prolongation, n (%) | 1 (2.7) | 0 (0.0) | 0.493 |
| BSA fenestration | 4 (10.8) | 1 (2.6) | 0.200 |
| VA agenesis, n (%) | 2 (5.4) | 3 (7.9) | 1.000 |
| VA hypoplasia | 12 (32.4) | 6 (15.8) | 0.111 |
| FPCA or ACA share common trunk | 5 (13.5) | 0 (0.0) | 0.025 |
| WMH characteristics | |||
| Fazekas score (IQR) | 3 (2-3) | 2 (2-3) | 0.158 |
ACA, anterior cerebral artery; BSA, basilar artery; CADASIL, cerebral autosomal dominant with subcortical infarcts and leukoencephalopathy; FPCA, fetal posterior cerebral artery; IQR, interquartile range; SE, standard error; SVD, small vessel disease. VA, vertebral artery.