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. 2020 Aug 18;10:1477. doi: 10.3389/fonc.2020.01477

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Copyright © 2020 Chen, Chen, Mu, Yang, Gu, Zhao, Liang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic depicting PTBP3 induced inhibition of differentiation of gastric cancer cells through alternative splicing of Id1. The loss of feedback regulation among Id1a, Id1b, and Hes1 may be a major cause of malignant transformation.