Table 1:
Raw data sample descriptions (mean, SD)
| Full MRI Sample | European Ancestry Subsample | |||
|---|---|---|---|---|
| Control | ADHD | Control | ADHD | |
| N | 208 | 293 | 113 | 199 |
| N(%) boys | 100 (48%) | 206(70%) | 60(53%) | 140(70%) |
| Age at scan | 10.31(1.6) | 10.26(1.6) | 10.23(1.4) | 10.12(1.5) |
| Family Income | 4.8(1.6) | 4.4(1.9) | 4.95(1.7) | 4.59(1.8) |
| Parent Conners (T) | ||||
| Inattention | 46.5(7.8) | 75.0(11.9) | 46.3(7.2) | 75.3(12.1) |
| Hyperactivity | 48.1(9.3) | 71.3(15.2) | 48.2(10.0) | 71.4(15.0) |
| Exec Function | 47.2(7.3) | 71.1(12.1) | 46.9(7.2) | 71.8(12.5) |
| Aggression | 48.8(8.7) | 54.7(12.5) | 49.2(8.9) | 54.1(12.2) |
| Teacher Conners (T) | ||||
| Inattention (T) | 46.9(7.7) | 67.1(11.4) | 47.3(7.5) | 66.6(11.2) |
| Hyperactivity (T) | 47.5(7.2) | 67.9(16.1) | 47.5(7.3) | 66.8(16.1) |
| Learning/ex (T) | 44.7(4.9) | 58.2(9.9) | 44.8(5.0) | 58.0(9.8) |
| Aggression (T) | 47.4(5.6) | 57.6(15.4) | 47.6(6.9) | 56.1(14.8) |
| MRI scores | ||||
| Mean framewise displacement | .180(.18) | .381(.53) | .167(.14) | .409(.61) |
| Total brain volume | 1211159(116433) | 1205166(107971) | 1229251(120601) | 1213321(105598) |
| Cerebellar volume | 108787(10834) | 108991(9631) | 110689(10816) | 108895(9411) |
| Thalamus | 15596(1487) | 15631(1464) | 15744(1479) | 15712(1484) |
| Caudate | 8804(1036) | 8842(1094) | 8795(1046) | 8882(1081) |
| Putamen | 12850(1369) | 12646(1262) | 12919(1497) | 12607(1221) |
| Globus pallidus | 3731(375) | 3676(359) | 3741(394) | 3684(362) |
| Hippocampus | 8117(783) | 8027(789) | 8214(768) | 8089(806) |
| Amygdala | 3262(438) | 3285(425) | 3333(423) | 3301(428) |
| Nucleus Accumb. | 1214(174) | 1191(161) | 1221(161) | 1208(159) |
| Polygenic Risk score | NA | NA | .473(.16) | .512(.143) |
|
|
||||
Conners Scores are T-scores based on national norms; ADHD medications are listed in Supplemental Table S1. PGS=polygenic score as explained in the text. All volume measures are given in mm3. Family income measures are based on the following scale: 1=less than $25,000, 2=$25,000–$35,000, 3=$35,000–$50,000, 4=$50,000–$75,000, 5=$75,000–$100,000, 6=$100,000–$130,000, 7=more than $150,000.