Table 3.
Brain volumes associated with PGC ADHD polygenic score.
| Region | PGS β‡ | P (FDR)‡ | PGS β | P (FDR) | Sex * PGS P (FDR) | PGS β, males | P (FDR), males | PGS β, females | P (FDR), females |
|---|---|---|---|---|---|---|---|---|---|
| Whole Brain | −0.107 | 0.0380 (0.342) | −0.147 | 0.0187 (0.168) | 0.254 (0.512) | −0.150 | 0.0207 (0.186) | −0.0231 | 0.787 (0.886) |
| Accumbens | 0.0676 | 0.184 (0.433) | 0.0305 | 0.622 (0.800) | 0.295 (0.512) | 0.0285 | 0.658 (0.741) | 0.137 | 0.106 (0.238) |
| Amygdala | 0.0682 | 0.127 (0.433) | 0.0515 | 0.344 (0.753) | 0.592 (0.592) | 0.0505 | 0.380 (0.731) | 0.0992 | 0.171 (0.309) |
| Caudate | 0.0108 | 0.811 (0.811) | 0.0368 | 0.502 (0.753) | 0.406 (0.512) | 0.0261 | 0.655 (0.741) | −0.0379 | 0.581 (0.748) |
| Cerebellum | −0.0283 | 0.515 (0.663) | 0.0181 | 0.733 (0.818) | 0.126 (0.423) | 0.0278 | 0.622 (0.741) | −0.119 | 0.071 (0.213) |
| Hippocampus | 0.0501 | 0.258 (0.464) | 0.0731 | 0.176 (0.753) | 0.455 (0.512) | 0.0744 | 0.179 (0.652) | 0.00241 | 0.975 (0.975) |
| Pallidum | 0.0598 | 0.192 (0.433) | 0.0128 | 0.818 (0.818) | 0.141 (0.423) | 0.0123 | 0.837 (0.837) | 0.149 | 0.0377 (0.170) |
| Putamen | 0.0335 | 0.466 (0.663) | −0.0630 | 0.254 (0.753) | 0.00241 (0.0217) | −0.0729 | 0.217 (0.652) | 0.224 | 0.00148 (0.0134) |
| Thalamus | −0.00907 | 0.798 (0.811) | −0.0322 | 0.456 (0.753) | 0.350 (0.512) | −0.0392 | 0.406 (0.731) | 0.0355 | 0.485 (0.727) |
‡
Effect and p-value from model without the sex interaction term (main effect).