Figure 7.

IDO2 deficient mice generate reduced antibody response to influenza. Wt, IDO1 ko, IDO2 ko, and dko C57BL/6 mice were infected with 200 TCID₅₀ influenza virus (A/PR/8/34). (A) Titers of anti-PR8 Ig were measured on days 0, 5, 7, and 10 by ELISA. Symbols represent individual mice and histograms show mean serum anti-PR8 Total Ig titer ± SEM for a minimum of n = 10 mice per group. (B) Symbols represent individual mice and histograms show mean serum anti-PR8 IgM vs. IgG titers ± SEM on day 10 from n = 20 wt, n = 15 IDO1 ko, n = 20 IDO2 ko, and n = 20 dko B6 mice. Data are pooled from 4 independent experiments. P-values were calculated by one way-ANOVA followed by comparison of means with Tukey's post-hoc multiple comparison correction. ^**p < 0.01, ^***p < 0.0001, n.s., not significant.