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. 2020 Aug 18;14:55. doi: 10.3389/fncir.2020.00055

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Copyright © 2020 Liu, Li, Wu, Dai, Chen, Huang, Zhang, Tian and Mei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lesion of SCN neurons reversed the decrease of the burst suppression ratio induced by MBL during continuous inhalation of 2.5% sevoflurane. (A,B) Typical examples of the BSR response under sevoflurane anesthesia in the sham group-administered PWL (A) or MBL (B). The orange and blue boxes indicate the duration of light exposure. (C,D) Effect of PWL (C) and MBL (D) on the electroencephalogram BSR during continuous inhalation of 2.5% sevoflurane in the sham group. The sham mice treated with MBL showed a significant 21% decrease (**) in the BSR during the first 10 min post-MBL and a 39% decrease (**) during the second 10 min post-MBL and a 56% decrease (***) during the last 10 min post-MBL compared to the sham pre-MBL 10 min (**p < 0.01 and ***p < 0.001 compared with sham pre-MBL 10 min, n = 9, RM one-way ANOVA, and Tukey’s multiple comparisons test with the Greenhouse-Geisser correction, F_{(1.765,14.12)} = 23.07). However, the sham-PWL-treated animals showed no significant difference in the BSR compared to sham pre-PWL (n.s. = not significant, compared with sham pre-PWL 10 min, n = 5, RM one-way ANOVA, and Tukey’s multiple comparisons test with the Greenhouse-Geisser correction, F_{(1.180,4.719)} = 1.340). (E,F) Typical examples of the BSR response under sevoflurane anesthesia in the SCNx group-administered PWL (E) or MBL (F). The orange and blue boxes indicate the duration of light exposure. (G,H) Effect of PWL (G) and MBL (H) on electroencephalogram BSR during continuous inhalation of 2.5% sevoflurane in the SCNx group. The SCNx mice treated with MBL showed no significant difference in BSR compared to the SCNx pre-MBL 10 min (n.s. = not significant compared with SCNx pre-MBL 10 min, n = 8, RM one-way ANOVA, and Tukey’s multiple comparisons test with the Greenhouse-Geisser correction, F_{(1.550,10.85)} = 3.516). SCNx PWL-treated animals showed no significant difference in the BSR compared to SCNx pre-PWL (n.s. = not significant compared with SCNx pre-PWL 10 min, n = 8, RM one-way ANOVA, and Tukey’s multiple comparisons test with the Greenhouse-Geisser correction, F_{(1.775,12.42)} = 1.005). PWL, polychromatic white light; MBL, monochromatic blue light.