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. 2020 Aug 18;14:55. doi: 10.3389/fncir.2020.00055

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Copyright © 2020 Liu, Li, Wu, Dai, Chen, Huang, Zhang, Tian and Mei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lesion of SCN neurons eliminated the increase in cortical EEG activity induced by MBL during continuous inhalation of 2.5% sevoflurane. (A,B) Representative electroencephalogram traces (upper) and electroencephalogram power spectrogram (lower) in the sham group-administered PWL (A) or MBL (B). Time 0 indicates the beginning of light stimulation during continuous sevoflurane anesthesia. The orange and blue lines indicate the 120 s intervals used for power spectral density comparisons. (C) PSD in the sham mice computed from 2 min before PWL (black) and 2 min after PWL (orange). (D) The sham mice treated with PWL showed no statistically significant difference in electroencephalogram power compared to sham pre-PWL (n.s. = not significant compared with sham pre-PWL, n = 5, paired Student’s t-tests). (E) PSD in the sham mice computed from 2 min before MBL (black) and 2 min after MBL (blue). (F) The sham mice treated with MBL showed increased electroencephalogram power in all of the frequency bands compared to sham pre-MBL (*p < 0.05 and **p < 0.01 compared with sham pre-MBL, n = 8, and paired Student’s t-tests). (G,H) Representative electroencephalogram traces (upper) and electroencephalogram power spectrogram (lower) in the SCNx group-administered PWL (G) or MBL (H). Time 0 indicates the beginning of light stimulation during continuous sevoflurane anesthesia. The orange and blue lines indicate the 120 s intervals used for power spectral density comparisons. (I) PSD in the SCNx mice computed from 2 min before PWL (black) and 2 min after PWL (orange). (J) The SCNx mice treated with PWL showed no statistically significant difference in electroencephalogram power compared to SCNx pre-PWL (n.s. = not significant compared with SCNx pre-PWL, n = 8, and paired Student’s t-tests). (K) PSD in the SCNx mice computed from 2 min before MBL (black) and 2 min after MBL (blue). (L) The SCNx mice treated with MBL showed no statistically significant difference in electroencephalogram power compared to SCNx pre-MBL (n.s. = not significant, compared with SCNx pre-MBL, n = 8, and paired Student’s t-tests). PWL, polychromatic white light; MBL, monochromatic blue light.