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. 2020 Aug 18;10:1622. doi: 10.3389/fonc.2020.01622

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Copyright © 2020 Cornelissen, Blanas, Zaal, van der Horst, Kruijssen, O’Toole, van Kooyk and van Vliet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockout of C1galt1c1 in tumor cells is associated with a decrease in antigen presentation and cytotoxic T cell activation. (A) Gene expression analysis in MC38-Tn^high cells compared to MC38-MOCK cells. Depicted are the log₂ fold change and FDR-adjusted p-values in a minus log 10 transformation. Differentially expressed genes (DEGs) (FDR < 0.05) are highlighted in orange. (B) Comparative analysis of DEGs in MC38-WT vs MC38-MOCK cells and MC38-Tn^high vs MC38-MOCK cells. (C) Significant enriched GO terms annotated to the 1348 DEGs in MC38-COSMC KO cells. (D) Expression profile (log2 normalized counts) of the genes involved in antigen presentation and T cell activation.