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. 2020 Aug 18;10:1459. doi: 10.3389/fonc.2020.01459

Table 2.

Univariate and multivariate analysis of the prognostic factors for recurrence-free survival in patients with GIST.

Variables Univariate analysis Multivariate analysis
HR (95%CI) P HR (95%CI) P
Gender 0.350
   Male 1
   Female 0.805 (0.511–1.268)
ECOG score 0.223
   0 1
   1 1.473 (0.880–2.466) 0.140
   2 1.774 (0.642–4.904) 0.269
Age 0.486
    <60 1
   ≥60 1.177 (0.744–1.860)
BMI (kg/m2) 0.154
    <18.5 1.937 (0.781–4.808)
   ≥18.5 1
Tumor size <0.001
    ≤ 2 1
   >2, ≤ 5 1.566 (0.617–3.972) 0.345
   >5, ≤ 10 3.784 (1.534–9.337) 0.004
   >10 12.285 (5.127–29.437) <0.001
Tumor location <0.001
   stomach 1
   Intestine 2.447 (1.411–4.244) 0.001
   Colorectum 3.664 (1.835–7.319) <0.001
   E–GIST 4.037 (2.133–7.642) <0.001
Mitotic index <0.001
    ≤ 5 1
   >5, ≤ 10 3.962 (1.996–7.865) <0.001
   >10 10.256 (5.769–18.232) <0.001
NIH risk category <0.001 <0.001
   Very low 1 1
   Low 1.683 (0.455–6.218) 0.435 1.615 (0.437–5.972) 0.472
   Intermediate 3.943 (1.100–14.135) 0.035 3.591 (0.998–12.915) 0.050
   High 10.681 (3.338–34.177) <0.001 9.280 (2.877–29.937) <0.001
Clavien–Dindo grade 0.715
    <3 1
   ≥3 0.878 (0.438–1.761)
FARI <0.001 0.031
   Low 1 1
   High 2.338 (1.492–3.663) 1.650 (1.047–2.601)
NLR 0.010
   Low 1
   High 2.314 (1.222–4.381)
PLR 0.003
   Low 1
   High 2.148 (1.290–3.575)
PNI <0.001
   Low 2.402 (1.518–3.801)
   High 1

FARI, fibrinogen–albumin ratio index; ECOG, Eastern Cooperative Oncology Group; BMI, body mass index; NIH, National Institute of Health; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutritional index; HR, hazard ratio; CI, confidence interval.