Figure 1.

Regulatory elements and chromatin landscape in the vicinity of the FXN TSS. University of California, Santa Cruz Genome Browser (GRCh37/hg19) presentation of chromatin modifications and other regulatory elements present in the FXN gene of an unaffected individual. Location of the GAA repeats is indicated by a red line. When possible, data obtained by the Encode consortium using NHDF are presented. Location of DNaseI hypersensitive sites and RNA polymerase II are shown. The presence of transcription-specific histone H3 covalent modifications (H3: K4me1, K4me2, K4me3, K9ac, K27ac, and K79me2) is presented. FXN, frataxin; NHDF, normal dermal human fibroblasts; TSS, transcription start site.