Table 2.
Fold Changes in Representative Immune Cells and Cytokines and Cytolytic Protein Gene Expression Levels Found in the Pseudopathogen-Activated Microenvironment 96 H After Treating Melanoma with Hot [225Ac]αMSH-PEG-Cy5-C′ Dots or Cold αMSH-PEG-Cy5-C′ Dots Versus Vehicle-Treated Controls
| Ratio of hot-to-control | Ratio of cold-to-control | |
|---|---|---|
| Cell type | ||
| MΦ macrophage | 0.29 | 0.11 |
| M1 macrophage | 3.1 | 2.1 |
| NK cell (activated) | 6.0 | 6.3 |
| CD8 T cell (naive) | 2.3 | 2.6 |
| CD8 T cell (activated) | 3.3 | 3.3 |
| Th1 cell | 6.2 | 3.0 |
| Regulatory T cell | 3.0 | 4.1 |
| Dendritic cell (immature) | ≫2 | ≫5 |
| Cytokines and cytolytic proteins | ||
| IL18 | 6.8 | 5.0 |
| IL12 | 8.9 | 8.6 |
| IFNγ | 7.6 | 8.5 |
| TNF | 3.6 | 3.4 |
| Perforin | ND | ND |
| Granzyme | 17.8 | 28.3 |