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Predicted Deleteriousness by Several in Silico Tools for the Variants Found in Neurotransmitter Genes
| Case ID | Gene | Transcript | Variant/AA change | SIFT | PolyPhen | PredictSNP2 | Mutation Taster | Mutation Assessor (FI score) |
|---|---|---|---|---|---|---|---|---|
| R150 | GABRG1 | NM_173536.3 | c.137A>G/p.Asp46Gly | D | Probably damaging | 87% D | D/AA changes/Protein Features/SS changes | Medium (2.11) |
| R171 | GRIK1 | NM_000830.4 | c.1282A>T/p.Asn428Tyr | D | Probably damaging | 87% D | D/AA/Protein/SS | Medium (3.43) |
AA, amino acid; FI, functional impact.
