Figure 1.

DCM pedigrees with SOS1 variants. Affection status was categorized using an ordinal grading scale. 0 (no cardiovascular disease or evidence of DCM), I (either left ventricular enlargement, LVE, without systolic function or systolic dysfunction without LVE), II (asymptomatic DCM), III (symptomatic DCM with or without medical therapy), IV (DCM requiring advanced interventions or resulting in DCM-related death). In all pedigrees, squares represent males, circles females. Diagonal lines indicate deceased individuals. Presence (+) or absence (−) of identified rare variants are indicated. Individuals for whom exome sequencing was completed are marked with an “E”.