Table 2.
Clinical characteristics of study participants.
| Individual | DCM | Age of Onset (y) | Age at Echo (y) | Height (cm) | LVIDD | Z-score | LVEF | ICD | Hrt. Tx. | Arrhyth. | Vital Status (Age in y, or age at death or heart transplant) | Comments / Additional Features |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pedigree A | ||||||||||||
| A.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Deceased (d.88, unk.) | No medical records, diabetes (reported), HTN (reported) |
| A.2 | Yes | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Deceased (d. 58, HF) | No medical records, reported affected |
| A.3 | Yes | 33 | 77 | 160 | 65 | 5.601031 | 52.5 | No | No | Yes | Alive (61) | |
| A.4 | Yes | 44 | 72 | 175 | 62 | 3.036178 | 25 | No | No | Yes | Deceased (d.57, DCM, HF) | Degenerative arthritis, gout, migraines, cholecystectomy |
| A.5 | No | n/a | n/a | 174 | 55 | 2.315058 | 60 | No | No | No | Alive (64) | |
| A.6 | No | n/a | n/a | 181.61 | 54 | 0.709736 | 47.5 | No | No | Yes | Alive (42) | HTN |
| A.7 | Yes | 22 | 22 | 183 | 63.5 | 3.011836 | 20 | Yes | Yes | Yes | Heart transplant (31) | Cardiorenal syndrome |
| A.8 | Yes | 14 | 14 | 165.1 | 75 | 6.30143 | n/a | Yes | Yes | No | Deceased (d. 22), Heart transplant (14) | |
| Pedigree B | ||||||||||||
| B.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | No | No | Deceased (d.74, HF) | HTN (reported) |
| B.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | No | No | No | Deceased (d.>89y, aortic dissection) | Alzheimer’s, HTN, cardiomegaly, coronary artery calcifications |
| B.3 | Yes | 56 | 66 | 170.2 | 66 | 5.358739 | 17 | Yes | No | No | Alive (76) | Hx doxorubicin, diabetes, hyperthyroid |
| B.4 | Yes | 61 | 63 | 162.6 | 57 | 3.406839 | 25 | Yes | No | Yes | Alive (75) | Asthma, hx 2mm circumflex coronary aneurysm |
| B.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | No | No | No | Deceased (d. 79, unk.) | |
| B.6 | Yes | 45 | 45 | 175.26 | 71 | 5.002545 | 42.5 | Yes | No | No | Alive (54) | WPW, diabetes |
| B.7 | No | n/a | n/a | n/a | n/a | n/a | n/a | No | No | No | Alive (53) | HTN, migraines, hysterectomy |
| Pedigree C | ||||||||||||
| C.1 | Yes | 69 | 69 | n/a | 78 | n/a | n/a | No | No | Yes | Deceased (d.70, HF) | |
| C.2 | No | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | No Medical Records |
| C.3 | Yes | 35 | 45 | 175.26 | 59 | 3.364278 | 40 | No | No | No | Alive (57) | HTN, hypothyroid |
| C.4 | Yes | 25 | 25 | 167.64 | 54 | 2.31695 | 25 | Yes | No | Yes | Alive (54) | MVP repair, breast neurofibromas, esophagitis, anemia |
| C.5 | No | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Alive (unk.) | No medical records |
| C.6 | Yes | 35 | 35 | n/a | n/a | n/a | n/a | No | No | Yes | Deceased (d.42, SCD) | No medical records, reported affected |
| C.7 | Yes | 22 | 22 | n/a | n/a | n/a | 20 | No | No | Yes | Alive (30) | No medical records, reported affected |
| Pedigree D | ||||||||||||
| D.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Deceased (unk.) | No medical records |
| D.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Deceased (unk.) | No medical records |
| D.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Deceased (unk.) | No medical records |
| D.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Alive (unk.) | No medical records |
| D.5 | Yes | 35 | 35 | 144 | 70 | 7.591059 | 27.5 | No | No | No | Deceased (d.49, unk.) | |
| Pedigree E | ||||||||||||
| E.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Deceased (d.80) | No medical records |
| E.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Deceased (d.80) | No medical records |
| E.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Alive (unk.) | No medical records |
| E.4 | Yes | 60 | 60 | 158.75 | 55 | 3.031521 | 25 | No | No | Yes | Alive (77) | |
| E.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | Alive (unk.) | No medical records |
| E.6 | Yes | 47 | 59 | 172.72 | 70 | 6.170558 | 20 | Yes | No | Yes | Deceased (d.75, unk.) | Cataracts, cholecystectomy, bladder suspension |
| E.7 | No | n/a | n/a | 178 | 47.7 | −1.86712 | 66 | No | No | No | Alive (53) | |
| E.8 | No | n/a | n/a | 157.48 | 48 | 0.950447 | 50 | No | No | No | Alive (49) | |
Abbreviations: Arrhyth, arrhythmia; DCM, dilated cardiomyopathy; HF, heart failure; Hrt Tx, heart transplant; HTN, hypertension; Hx, history; ICD, implantable cardioverter defibrillator; LVEF, left ventricular ejection fraction; LVIDD, LV internal dimension in diastole; MVP, mitral valve prolapse; n/a, not applicable; SCD, sudden cardiac death; unk, unknown; WPW, Wolff-Parkinson-White Syndrome.