Figure 1.

MRI scan of Patient 2 at age 41 illustrates reduced white matter. (A and B) T₂-weighted axial sections showing the diffusely increased signal in the cerebral white matter; however, there is a thin, normal signal in the corpus callosum and the internal capsule. (C and D) T₁-weighted images showing the reduced amount of white matter: note the thinness of the corpus callosum and of the fingers of white matter extending into cortical gyri in C. Thinning of the corpus callosum and of the cervical spinal cord can be observed in D. Reference T₁ and T₂ MRI images of healthy individuals can be found in publicly available MRI brain atlases, such as the Whole Brain Atlas by the Harvard Medical School http://www.med.harvard.edu/AANLIB/cases/caseNA/pb9.htm or the IMAIOS webservice https://www.imaios.com/en.