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. 2020 May 18;143(5):1383–1399. doi: 10.1093/brain/awaa080

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© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Western blot of myelin extracts from PMD and control human brain show altered levels of myelin proteins. Ctl1 is stored tissue from 70-year-old brain and Ctl2 is fresh biopsy material from 2-year-old brain white matter. Myelin was extracted from tissue that was composed of a mixture of grey and white matter or tissue that was composed almost entirely of white matter. For PLP and MBP analysis, 0.25 μg of the PMD myelin was loaded; in the control patients 0.25 μg (equal symbol) and 0.5 μg (×2) of the samples were loaded onto the gel. For CNP and MAG analysis, 1.5 μg of the PMD myelin and 1.5 μg (equal symbol) and 3 μg (×2) of the control samples were loaded onto the gel. Graphs provide semiquantitative data reflecting band intensities. The y-axis values are the same in the two graphs. Blots were cropped for display purposes. Full-length blots are available in the Supplementary material.