Table 4.

Clinical, quantitative sensory testing and histological outcomes in CTS patients who did not undergo surgery

	Baseline	Follow-up	P-value
Questionnaires
Mean VAS (SD)
Pain	2.3 (3.0)	1.1 (1.5)	0.268
Numbness	3.8 (3.2)	1.6 (2.2)	0.063
Paraesthesia	3.9 (2.8)	2.6 (3.0)	0.271
Mean Boston scale (SD)
Symptoms	2.3 (0.6)	2.0 (0.6)	0.215
Function	1.9 (0.6)	1.6 (0.5)	0.171
Mean NPSI (SD)	9.7 (7.7)	5.6 (5.8)	0.186
Quantitative sensory testing
CDT, °C	−3.40 (1.83)	−3.23 (1.65)	0.805
WDT, °C	4.07 (2.39)	3.96 (1.98)	0.914
TSL, °C	6.53 (2.72)	6.90 (3.73)	0.874
MDT, mN	1.27 (1.48)	1.10 (1.16)	0.980
VDT, x/8	7.44 (0.63)	7.28 (1.15)	0.443
CPT, °C	15.31 (8.06)	11.38 (8.68)	0.022
HPT, °C	41.12 (2.19)	42.54 (3.00)	0.135
MPT, mN	100.5 (66.9)	111.4 (92.7)	0.565
MPS, 0–100	0.95 (0.84)	0.56 (0.59)	0.042
PPT, kPa	325.5 (97.3)	356.4 (109.7)	0.069
WUR, ratio	1.64 (0.66)	2.24 (0.81)	0.033
Histological parameters
IENFD	6.94 (3.09)	5.61 (3.41)	0.021
Meissner corpuscle density	0.47 (0.31)	0.20 (0.24)	0.010
Subepidermal plexus nerve fibre length	137.0 (176.5)	132.6 (110.1)	0.433
PGP+ dermal axon bundles	5.74 (4.20)	4.42 (1.98)	0.299
Ratio of PGP+ dermal bundles containing MBP	1.45 (0.42)	1.57 (0.60)	0.710
Nodal length, median [IQR]	2.00 [1.01]	2.72 [2.63]	0.023
% Elongated nodes, median [IQR]	0.00 [4.55]	6.66 [22.22]	0.063
Internodal length	82.8 (25.88)	70.24 (16.83)	0.062
G-ratio	0.84 (0.07)	0.89 (0.06)	0.107

Data are presented as mean (SD) unless indicated otherwise.

CDT = cold detection threshold; CPT = cold pain threshold; HPT = heat pain threshold; IENFD = intraepidermal nerve fibre density (per mm epidermis); MDT = mechanical detection threshold; MPS = mechanical pain sensitivity; MPT = mechanical pain threshold; PPT = pressure pain threshold; TSL = thermal sensory limen; VDT = vibration detection threshold; WDT = warm detection threshold; WUR = wind-up ratio.