TABLE 1.
Results from simulations controlling imbalance in five covariates
| Observed P-values in the original study | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Clinical center | NIHSS | Age | OTT | Glucose | Stroke subtype | Sex | Fibrinogen | Weight | Systolic BP | Diastolic BP | |
| .999 | .140 | .029 | .866 | .780 | .073 | .627 | .181 | .011 | .597 | .281 | |
| Minimization | |||||||||||
| P-Value percentiles | Included in randomization method | Not included in randomization method | |||||||||
| Clinical center | NIHSS | Age | OTT | Glucose | Stroke subtype | Sex | Fibrinogen | Weight | Systolic BP | Diastolic BP | |
| 2.5% | .469 | .223 | .225 | .266 | .115 | .047 | .026 | .023 | .035 | .026 | .026 |
| 5% | .601 | .300 | .303 | .336 | .178 | .082 | .052 | .051 | .065 | .053 | .050 |
| 10% | .733 | .397 | .386 | .422 | .261 | .143 | .105 | .104 | .125 | .100 | .098 |
| Median | .962 | .737 | .721 | .760 | .653 | .542 | .500 | .507 | .526 | .499 | .504 |
| Minimal sufficient balance | |||||||||||
| Included in randomization method | Not included in randomization method | ||||||||||
| Clinical center | NIHSS | Age | OTT | Glucose | Stroke subtype | Sex | Fibrinogen | Weight | Systolic BP | Diastolic BP | |
| 2.5% | .210 | .268 | .266 | .269 | .261 | .037 | .030 | .031 | .033 | .029 | 0.26 |
| 5% | .269 | .297 | .295 | .293 | .291 | .071 | .057 | .055 | .063 | .056 | .052 |
| 10% | .314 | .335 | .330 | .329 | .320 | .131 | .103 | .108 | .114 | .106 | .099 |
| Median | .666 | .629 | .610 | .623 | .623 | .533 | .500 | .504 | .522 | .494 | .501 |