TABLE 2.
Results from simulations controlling imbalance in 11 covariates
| Observed P-values in the original study | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Clinical center | NIHSS | Age | OTT | Glucose | Stroke subtype | Sex | Fibrinogen | Weight | Systolic BP | Diastolic BP | |
| .999 | .140 | .029 | .866 | .780 | .073 | .627 | .181 | .011 | .597 | .281 | |
| Minimization | |||||||||||
| P-Value boundary | Included in randomization method | ||||||||||
| Clinical center | NIHSS | Age | OTT | Glucose | Stroke subtype | Sex | Fibrinogen | Weight | Systolic BP | Diastolic BP | |
| 2.5% | .257 | .151 | .118 | .152 | .060 | .231 | .229 | .097 | .138 | .125 | .102 |
| 5% | .376 | .194 | .177 | .229 | .102 | .289 | .338 | .143 | .183 | .185 | .152 |
| 10% | .512 | .279 | .249 | .334 | .159 | .411 | .457 | .225 | .263 | .269 | .225 |
| Median | .894 | .687 | .612 | .706 | .566 | .812 | .804 | .619 | .630 | .641 | .633 |
| Minimal sufficient balance | |||||||||||
| Included in randomization method | |||||||||||
| Clinical center | NIHSS | Age | OTT | Glucose | Stroke subtype | Sex | Fibrinogen | Weight | Systolic BP | Diastolic BP | |
| 2.5% | .158 | .263 | .261 | .260 | .256 | .156 | .256 | .254 | .244 | .241 | .250 |
| 5% | .249 | .288 | .286 | .300 | .283 | .226 | .288 | .278 | .288 | .267 | .283 |
| 10% | .318 | .327 | .328 | .336 | .311 | .293 | .330 | .325 | .326 | .313 | .324 |
| Median | .666 | .618 | .615 | .604 | .617 | .587 | .651 | .624 | .632 | .632 | .634 |