Table 4.

Bivariable segmented regression analysis accessing different substance use time trend before and after opioid agonist therapy initiation among 1107 people who use illicit drugs in Vancouver, British Columbia, Canada.

Substance type	Pre-treatment trend, per year increase		Post-treatment trend, per year increase		Compare trends
	Odds Ratio (95% CI)	P	Odds Ratio (95% CI)	P	P
Heroin	1.17 (1.10, 1.24)	<0.001	0.80 (0.77, 0.82)	<0.001	<0.001
Illicit prescription opioid	1.05 (1.00, 1.10)	0.036	0.89 (0.85, 0.92)	<0.001	<0.001
Cocaine	0.87 (0.83, 0.92)	<0.001	0.83 (0.80, 0.85)	<0.001	0.107
Crack cocaine	1.00 (0.94, 1.06)	0.980	1.02 (0.98, 1.05)	0.311	0.637
Crystal methamphetamine	1.11 (1.05, 1.18)	<0.001	1.02 (0.99, 1.06)	0.132	0.018
Cannabis	0.95 (0.92, 0.99)	0.017	0.97 (0.94, 0.99)	0.013	0.520
Daily alcohol	0.91 (0.85, 0.99)	0.020	1.04 (0.98, 1.10)	0.185	0.011
Benzodiazepines	0.85 (0.80, 0.90)	<0.001	0.74 (0.68, 0.80)	<0.001	0.008

CI confidence interval.