Fig. 1 |. Proposed mechanisms of mitochondrial dysfunction in individuals with frailty.
Left, a healthy mitochondrion. Right, putative mechanisms of mitochondrial dysfunction in individuals with frailty. Reduced carnitine content in mitochondria hampers the entrance of long-chain fatty acids (LCFA), causing a decrease in energy production (ATP) and an increase in generation of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2). LC, long-chain.