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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Nat Rev Endocrinol. 2020 Mar;16(3):133–134. doi: 10.1038/s41574-020-0319-y

Fig. 1 |. Proposed mechanisms of mitochondrial dysfunction in individuals with frailty.

Fig. 1 |

Left, a healthy mitochondrion. Right, putative mechanisms of mitochondrial dysfunction in individuals with frailty. Reduced carnitine content in mitochondria hampers the entrance of long-chain fatty acids (LCFA), causing a decrease in energy production (ATP) and an increase in generation of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2). LC, long-chain.

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