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. 2020 Aug 30;8(2):e001072. doi: 10.1136/jitc-2020-001072

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Kinetics of HBV DNA during ICI treatment. Kinetics of HBV DNA during ICI treatment in (A) patients with HBV DNA >100 IU/mL on NUCs, and (B) patients with HBV not on NUCs. Of 19 patients with HBV DNA >100 IU/mL on antiviral therapy, nine developed early tumor progression and short survival (<3 months), and three did not have significant ALT elevation during ICI treatment so that their followed data of HBV viral load were unavailable. ALT, alanine aminotransferase; HBV, hepatitis B virus; ICI, immune checkpoint inhibitor; NUCs, nucleos(t)ide analogs.