PSP neuropathology may be associated with a number of different clinical phenotypes (shown in light blue boxes with rounded edges). Other neuropathologies that may also present with these clinical phenotypes are shown in the lower row. Green: Tau, Orange: alpha-synuclein, Yellow: Alzheimer’s disease, Purple: TDP-43. Abbreviations: PAGF: pure akinesia freezing of gait, CBS: corticobasal syndrome, bvFTD: behavioral variant FTD, PPA: primary progressive aphasia, PLS: primary lateral sclerosis, PD/DLB: Parkinson’s Disease/dementia with Lewy bodies, MSA: multiple systems atrophy, CBD: corticobasal degeneration, PSP: progressive supranuclear palsy, AD: Alzheimer’s disease, TDP-43: TAR DNA binding protein 43.