Table 1.
Characteristics of Patients With GH Deficiency in the KIGS Database who Have History of Childhood Cancer (n = 1149)
| Male | 733 | 64% |
|---|---|---|
| Median age of GHT start (y) | 8.4 | 5.1, 11.6 |
| Median peak GH (ng/mL) | 2.8 | 0.5, 9.5 |
| Median duration GHT (y) | 7.5 | 5.5, 11.0 |
| Median GH dose (mg/kg/wk) | 0.18 | 0.12, 0.26 |
| Tumor groups | ||
| Craniopharyngioma total | 431 | 38% |
| Cranial RT | 137 | 32% |
| No RT | 268 | 62% |
| Other/unknown | 26 | 6% |
| Leukemia total | 134 | 12% |
| TBI | 71 | 53% |
| No TBI | 52 | 39% |
| Other/unknown | 11 | 8% |
| Medulloblastoma total | 224 | 19% |
| Craniospinal RT | 189 | 84% |
| Other/unknown | 35 | 16% |
| Other tumora | 360 | 31% |
Median and 10th, 90th percentiles are presented for continuous variables and Ns and % are for categorical variables.
Abbreviations: GHT, GH therapy; RT, radiation therapy; TBI, total body irradiation.
“Other” tumor group and unknown RT groups are excluded from analysis.
a Other tumor diagnoses: germinoma (dysgerminoma, pinealoma) 65; tumor of the pituitary/hypothalamic area 50; astrocytoma 41; ependymoma 35; glioma 35, solid tumor 27; nasopharyngeal tumor 23; lymphoma other 7; Hamartoma 6; non-Hodgkin lymphoma 4; other cranial tumors 67.