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. 2020 Jul 13;2(1):vdaa087. doi: 10.1093/noajnl/vdaa087

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© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — In vivo growth and immunohistochemistry. (A) Relative growth rates over time since the implantation of mixed unsorted (invasive margin or tumor core) cell xenografts (blue and purple lines), 5-ALA/FACS-negative cells (with no measurable tumor after day 20, green lines), and 5-ALA/FACS-positive invasive cells (red line), showing no growth for 5-ALA/FACS-negative cells and quicker growth for 5-ALA/FACS positive compared to unsorted mixed cells. (B) H&E of patient GBM (×40) from which a 5-ALA/FACS-positive xenograft was derived. (C) H&E of a flank xenograft in mouse, demonstrating GBM-like morphology. (D) Positive GFAP (astrocytic marker) IHC for mouse 5-ALA/FACS-positive GBM xenograft. (E) Positive IHC for Ki67 (proliferative marker) for mouse flank 5-ALA/FACS-positive GBM xenograft. (F) Positive IHC for vimentin (mesenchymal marker) in mouse 5-ALA/FACS-positive GBM xenograft (all scale bars 100 μm).