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. 2020 Aug 20;16(8):e1008064. doi: 10.1371/journal.pcbi.1008064

Table 1. Model parameters fixed from previous studies.

Parameter Meaning Value Units Citation
dT Per capita death rate of uninfected CD4+ T cells 0.01 day-1 Ref. [18]
dI Per capita death rate of productively infected CD4+ T cells 0.5 day-1 Ref. [18]
c Viral clearance rate 38 day-1 Refs. [22, 32, 33]
kE Per capita proliferation rate of effectors 0.1 day-1 Refs. [34, 35]
qc* Half-maximal Hill function threshold for exhaustion 0.5 Ref. [19]
n Hill coefficient for exhaustion 4 Ref. [19]
dq Exhaustion reversal rate constant 0.1 day-1 Ref. [19]
A1dose Estimated dose of the bNAb 3BNC117 65000# μg Ref. [10]
A2dose Estimated dose of the bNAb 10-1074 65000# μg Ref. [10]
ϵRTI Efficacy of ART (reverse transcriptase inhibitor) 0.9 Ref. [18, 36, 37]
ϵPI Efficacy of ART (protease inhibitor) 0.95 Ref. [18, 36, 37]

# Nishimura et al. administer 10 mg/kg of bNAbs to the macaques, and we assume an average body weight of 6.5 kg.