Table 1. Model parameters fixed from previous studies.
Parameter | Meaning | Value | Units | Citation |
---|---|---|---|---|
dT | Per capita death rate of uninfected CD4+ T cells | 0.01 | day-1 | Ref. [18] |
dI | Per capita death rate of productively infected CD4+ T cells | 0.5 | day-1 | Ref. [18] |
c | Viral clearance rate | 38 | day-1 | Refs. [22, 32, 33] |
kE | Per capita proliferation rate of effectors | 0.1 | day-1 | Refs. [34, 35] |
Half-maximal Hill function threshold for exhaustion | 0.5 | − | Ref. [19] | |
n | Hill coefficient for exhaustion | 4 | − | Ref. [19] |
dq | Exhaustion reversal rate constant | 0.1 | day-1 | Ref. [19] |
Estimated dose of the bNAb 3BNC117 | 65000# | μg | Ref. [10] | |
Estimated dose of the bNAb 10-1074 | 65000# | μg | Ref. [10] | |
ϵRTI | Efficacy of ART (reverse transcriptase inhibitor) | 0.9 | − | Ref. [18, 36, 37] |
ϵPI | Efficacy of ART (protease inhibitor) | 0.95 | − | Ref. [18, 36, 37] |
# Nishimura et al. administer 10 mg/kg of bNAbs to the macaques, and we assume an average body weight of 6.5 kg.