Table 2.
Respiratory variables on Days 1, 3, and 7 of mechanical ventilation
| Variable | Day 1 (n = 267)* | Day 3 (n = 252)* | Day 7 (n = 206)* | P Value† | q Value‡ |
|---|---|---|---|---|---|
| Pco2 | 44 (38–52) | 46 (41–52) | 50 (43–56) | <0.001 | <0.001 |
| PaO2:FiO2 | 103 (82–134) | 138 (106–177) | 138 (109–168) | <0.001 | <0.001 |
| Exhaled minute volume, L/min | 9.39 (8.13–11.33) | 9.99 (8.50–11.70) | 10.10 (8.60–12.17) | 0.039 | 0.049 |
| Tidal volume/predicted weight, cc/kg | 7.01 (6.13–8.10) | 6.38 (6.00–6.97) | 6.57 (6.14–7.30) | <0.001 | <0.001 |
| Static compliance, cm H2O | 28 (23–38) | 31 (25–40) | 31 (23–40) | 0.11 | 0.12 |
| Driving pressure, cm H2O | 14.0 (11.0–17.2) | 12.0 (9.0–15.2) | 13.0 (10.0–16.8) | 0.007 | 0.011 |
| Plateau pressure, cm H2O | 25.0 (21.0–29.0) | 24.0 (20.0–28.0) | 25.0 (22.0–29.0) | 0.2 | 0.2 |
| PEEP, cm H2O | 10.0 (8.0–12.0) | 12.0 (10.0–14.0) | 12.0 (8.0–14.0) | 0.002 | 0.003 |
| Ventilatory ratio | 1.79 (1.47–2.27) | 1.91 (1.55–2.39) | 2.08 (1.71–2.52) | <0.001 | <0.001 |
Definition of abbreviations: FiO2 = fraction of inspired oxygen; PaO2 = arterial oxygen pressure; Pco2 = partial pressure of carbon dioxide; PEEP = positive end-expiratory pressure.
*
Data presented as median (interquartile range).
†
Statistical test: Kruskal-Wallis.
‡
False discovery rate correction for multiple testing.