Table 1.
Characteristics of 50 patients with SARS-CoV-2–induced ARDS
| Characteristic | Median (IQR) or n (%) |
|---|---|
| Baseline characteristics | |
| Age, yr | 66 (57–74) |
| Male | 36 (72) |
| BMI, kg/m2 | 27.68 (26.43–30.39) |
| Smoking status* | |
| Never | 23 (56) |
| Current | 4 (10) |
| Former | 14 (34) |
| Alcohol consumption habit | 6 (12) |
| APACHE II score at ICU admission | 13 (11–18) |
| SOFA score upon ARDS diagnosis | 7 (6–9) |
| Time from hospital admission to ICU admission, d | 2 (1–3.75) |
| Time from ICU admission to intubation, d | 1 (0–1) |
| Coinfection | 2 (4) |
| Oxygen therapy and NIV before intubation† | |
| Venturi and nonrebreathing oxygen mask | 43 (93) |
| High-flow oxygen therapy | 23 (50) |
| NIV | 5 (11) |
| ARDS severity | |
| Mild | 12 (24) |
| Moderate | 22 (44) |
| Severe | 16 (32) |
| Management factors | |
| Prone position | 11 (22) |
| Neuromuscular blockade use | 24 (48) |
| Recruitment maneuvers | 18 (36) |
| Vasopressor use | 16 (32) |
| Corticosteroid therapy | 18 (36) |
| Laboratory findings‡ | |
| Hemoglobin, g/dl | 12.80 (11.83–13.40) |
| White blood cell count, ×109/L | 8.11 (6.26–11.42) |
| Lymphocyte count, ×109/L | 0.60 (0.40–0.90) |
| Platelet count, ×109/L | 219 (174–274) |
| Creatinine, mg/ml | 0.98 (0.77–1.45) |
| Sodium, mEq/L | 138 (136–140) |
| Potassium, mEq/L | 3.90 (3.60–4.30) |
| Aspartate aminotransferase, U/L | 65 (48–82) |
| Alanine aminotransferase, U/L | 45 (28–76) |
| Total bilirubin, mg/dl | 0.50 (0.40–0.90) |
| γ-Glutamyltransferase, U/L | 54 (36–105) |
| Lactate, mmol/L | 1.33 (1–1.59) |
| Alkaline phosphatase, U/L | 67 (53–86) |
| Lactate dehydrogenase, U/L | 442 (386–541) |
| Albumin, g/L | 36 (33–38) |
| D-dimer, ng/ml | 1,100 (800–3,800) |
| Ferritin, ng/ml | 1,436.50 (951.25–2,149.25) |
| Procalcitonin, ng/ml | 0.27 (0.17–0.97) |
| C-reactive protein, mg/dl | 15.68 (9.64–27.03) |
| Outcomes§ | |
| Hospital mortality | 15 (34) |
| Mortality at Day 28 | 10 (20) |
| Ventilator-free at Day 28, d | 9 (0–16) |
| ICU-free at Day 28, d | 0 (0–9) |
| Hospital length of stay, d | 36 (24–44) |
| ICU length of stay, d | 26 (17–34) |
| Tracheostomy | 30 (60) |
Definition of abbreviations: APACHE II = Acute Physiology and Chronic Health Evaluation II; ARDS = acute respiratory distress syndrome; BMI = body mass index; ICU = intensive care unit; IQR = interquartile range; NIV = noninvasive ventilation; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; SOFA = sequential organ failure assessment.
*
Missing data from nine patients.
†
Missing data from four patients.
‡
Laboratory findings upon ARDS diagnosis.
§
Six patients were still in the hospital after follow-up ending.