Table 2.
Gas exchange, pulmonary mechanics, and VILI of 50 patients with SARS-CoV-2–induced ARDS upon ARDS diagnosis
| Measure | Median (IQR) |
|---|---|
| Arterial blood gas | |
| pH | 7.31 (7.28–7.37) |
| PaCO2, mm Hg | 47 (42.9–53.4) |
| PaO2, mm Hg | 107 (88.5–133.6) |
| PaO2/FiO2 | 174 (128–232) |
| Ventilatory ratio* | 1.93 (1.55–2.23) |
| Ventilator settings, pulmonary mechanics, and other variables associated with VILI | |
| Vt/PBW, ml/kg | 6.78 (6.30–7.32) |
| Respiratory rate, breaths/min | 22 (20–23) |
| PEEP, cm H2O | 13 (11–14) |
| FiO2, % | 62 (53–76) |
| Peak inspiratory pressure, cm H2O | 32 (29–34) |
| End-inspiratory plateau pressure, cm H2O | 23 (21–25) |
| Driving pressure, cm H2O† | 11 (9–13) |
| Mechanical power, J/min‡ | 22.32 (18.49–28.10) |
| Crs, ml × cm H2O−1§ | 40.13 (32.88–51.68) |
Definition of abbreviations: ARDS=acute respiratory distress syndrome; Crs = static compliance of the respiratory system; FiO2 = fraction of inspired oxygen; IQR = interquartile range; PaCO2 = partial pressure of carbon dioxide; PaO2 = partial pressure of oxygen; PBW = predicted body weight; PEEP = positive end-expiratory pressure; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; VILI = ventilation-induced lung injury; Vt = tidal volume.
Ventilatory ratio is defined as (minute ventilation [ml/min] × PaCO2 [mm Hg])/(PBW × 100 × 37.5).
Driving pressure is the difference between plateau pressure and PEEP.
Mechanical power was calculated following previously published formulas (11).
Crs is the ratio of tidal volume to driving pressure.