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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Nat Catal. 2019 Aug 12;2(9):756–762. doi: 10.1038/s41929-019-0330-7

Fig. 1. α-Branched amines.

Fig. 1.

a, Representative examples of hundreds of approved pharmaceuticals that contain α-branched amine motifs (branch site highlighted by pink spheres). b, α-Branched amine synthesis with C–C bond formation at the branch site by addition of organometallic reagents to imines. c, α-Branched amine synthesis with C–C bond formation at the branch site from preexisting amines. d, Single step method to form α-branched amines from readily available C–H bond substrates, alkenes and aminating agents with formation of both C–C and C–N bonds at the branch site.