Figure 2.

Gene expression analysis in ACE2 (angiotensin-converting enzyme 2)-expressing type II alveolar (AT2) cell population. (A) Violin plots of expression for ACE2 and select cell type–specific marker genes significantly upregulated in distinct lung cell clusters from an Asian male donor. AGER is a type I alveolar cell marker, SFTPC (SPC) is an AT2 cell marker, SCGB3A2 is a club cell marker, TPPP3 is a ciliated cell marker, CD68 is a macrophage marker, and PTPRC (CD45) is a panimmune cell marker. (B) Dot plot of gene ontology enrichment analysis demonstrating enriched virus-related biological processes in the ACE2-expressing AT2 population. AT1 = type I alveolar; NK = natural killer.