Table 1.

A summary of model features utilized in five MDS prognostic scoring systems, and the resulting c-index of each.

Scoring System	Model Features	c-index
International Prognostic Scoring System (IPSS)	Karyotype categories [3], simple BM blasts % Cytopenias	0.65
Revised International Prognostic Scoring System (IPSS-R)	Karyotype categories [5], complex BM blasts % Hgb Platelets ANC	0.67
MD Anderson Cancer Center (MDACC)	Karyotype categories [2], simple BM blasts % Hgb Platelets WBC Age Performance status Prior transfusion	0.65
World Health Organization-Based Prognostic Scoring System (WPSS)	Karyotype categories [3], simple WHO category Transfusion requirement	0.65
Nazha et al. Geno-clinical model [13]	Cytogenetic categories of IPSS-R [5], complex BM blasts % Hgb Platelets WBC Age WHO category Secondary vs de novo MDS TP53, RUNX1, ANC, STAG2, SRSF2, NPM1, PHF6, IDH1, EZH2, and SF3B1	0.71